New Brain Chemical Identified as Key to Overcoming Bad Habits

WHO:

Inc - Scientists involved in the research are not named in the article.

WHAT:

Inc - A neurotransmitter has been identified that signals the brain to abandon old routines and adapt to new changes.

Science Daily - Researchers found that disappointment triggered a surge of the neurotransmitter acetylcholine, which made mice more likely to try new strategies.

Science Daily - When acetylcholine was blocked, mice became less flexible and more likely to stick with outdated choices.

WHERE:

Science Daily - The research involved mice navigating a virtual maze.

HOW:

Science Daily - The study observed the effects of disappointment on mice and measured the resulting changes in behavior related to the neurotransmitter acetylcholine.

(UPDATED June 8, 2026 23:20 UTC)

Scientists have identified a neurotransmitter that signals the brain to abandon old routines and adapt to new changes, specifically through the effects of disappointment. In a study involving mice navigating a virtual maze, researchers discovered that disappointment triggered a surge of acetylcholine, making the mice more likely to try new strategies, while blocking this neurotransmitter led them to stick with outdated choices. This research highlights the crucial role of acetylcholine in behavioral flexibility and decision-making.