Christina Applegate Says MS Diagnosis Was Wrong, Health Fight Resets

WHO:

NY Post - Actress Christina Applegate discussed her multiple sclerosis diagnosis and health.

Variety - Christina Applegate shared the news on her podcast, “MeSsy.”

WHAT:

NY Post - Applegate said she had been misdiagnosed with multiple sclerosis (MS), describing the impact with the words, “I lost everything.”

NY Post - Applegate said, “You don’t get misdiagnosed and then all of the sudden I’m better.”

Variety - Applegate said new technology led to the discovery that she had been misdiagnosed with MS.

Variety - In a tearful, two-part podcast episode, Applegate said, “I’m back at square one,” and called the situation a “Mindf—.”

WHEN:

Variety - Applegate returned to “MeSsy” after a seven-month break from the podcast due to her health.

WHY:

Variety - Applegate had taken a break from podcasting because of her health.

Variety - New technology prompted the discovery of the MS misdiagnosis.

HOW:

Variety - Applegate disclosed the diagnosis update while speaking tearfully in a two-part episode of “MeSsy.”

(UPDATED October 20, 2026 13:09 UTC)

Christina Applegate said new technology revealed that she had been misdiagnosed with multiple sclerosis, sharing the news tearfully on her podcast, “MeSsy.” After a seven-month break from the show due to her health, Applegate said, “I’m back at square one,” and described the situation as a “Mindf—.” She also said, “I lost everything,” adding that a misdiagnosis doesn’t suddenly mean she is better.