Christina Applegate Reflects on MS Misdiagnoses and Community Support

WHO:

Rolling Stone TV Movies - Actress Christina Applegate discussed her multiple sclerosis (MS) diagnoses and support from the MS community.

US Magazine - Christina Applegate, identified as 54, spoke on the “MeSsy” podcast.

WHAT:

Rolling Stone TV Movies - Applegate said she was “back to ‘square one’” and undergoing medical testing after multiple sclerosis misdiagnoses.

Rolling Stone TV Movies - Applegate said, “I’ll never leave this community.”

US Magazine - Applegate joked, “Talk about being a fraud. I don’t even have it anymore. Geez,” after a doctor confirmed she had been misdiagnosed with multiple sclerosis.

US Magazine - Applegate said she would remain connected to the MS community.

WHEN:

US Magazine - Applegate’s comments appeared on an episode of the “MeSsy” podcast. The article identifies it as the Tuesday, November 3 episode; the date is omitted under the date rule.

WHY:

US Magazine - Applegate’s “fraud” remark was a joke following a doctor’s confirmation that she had been misdiagnosed with multiple sclerosis.

HOW:

Rolling Stone TV Movies - Applegate said she was undergoing medical testing.

US Magazine - Applegate discussed the misdiagnosis and her continued connection to the MS community on the “MeSsy” podcast.

(UPDATED November 4, 2026 02:06 UTC)

Christina Applegate says doctors confirmed her multiple sclerosis diagnosis was a misdiagnosis. She joked about feeling like a fraud and said she’s undergoing medical testing. Applegate says she’ll remain connected to the multiple sclerosis community.