Analysis Finds Escitalopram Better at Preventing Depression Relapse

WHO:

BBC - The study’s authors said the findings could help prescribers and patients make decisions about antidepressant treatment.

BBC News - The article reported that three antidepressant pills outperformed Prozac in preventing relapse.

WHAT:

BBC - An analysis found that escitalopram was more effective at preventing depression relapse.

BBC News - Three pills came top and outperformed Prozac for preventing relapse in a large number of patients.

BBC - The study authors said: “Nevertheless, our study can help inform the decisions that prescribers and patients make together: if you start an antidepressant, choose one that not only helps you to get well, but also keeps you well.”

WHY:

BBC - The analysis was intended to help prescribers and patients choose an antidepressant that both helps patients recover and helps prevent them from becoming unwell again.

HOW:

BBC - The analysis compared antidepressants’ effectiveness at preventing relapse.

(UPDATED November 11, 2026 09:00 UTC)

A major analysis found escitalopram was more effective at preventing depression relapse than Prozac. Three antidepressants performed best, offering patients and prescribers useful choices for ongoing treatment. The findings could help people select medication that supports recovery and prevents relapse.